Gladstone Academy has been listed on the National Register of Historic Places for its significant in the area of education. Established ca. 1894, the school was the only school in the Village of Misenheimer, filling a critical educational need for local children and boarders, until the Ebenezer C. Mitchell Home and School relocated to Misenheimer in 1910, absorbed Gladstone Academy, and grew to become Pfeiffer University. Gladstone Academy was sponsored by agencies of the Methodist Episcopal Church, a denomination that had considerable educational outreach in the post-Civil War South, augmenting the meager educational offerings by local governments prior to the era of rural school consolidation in the 1920s. In1910 the building was converted for use as a church and was used as such until the mid-1940s when its congregation merged with another, and the building was sold to private owners. The Village of Misenheimer purchased it in 2011 and has been rehabilitating it for public use.
Hanbury Preservation Consulting prepared the nomination and the school was designated in April 2025.