The Goldsboro Woman's Club building was constructed in 1927 as the headquarters for the Goldsboro Woman's Club, established in 1899. The club was one of dozens of such clubs across North Carolina and thousands across the nation created in the late nineteenth and early twentieth centuries. The clubs provided women with an outlet for charitable outreach and companionship, and a vehicle to organize campaigns for social betterment. The Goldsboro club established a kindergarten for the children of millworkers, advocated for public health measures, and began the local public library. The members of the Goldsboro Woman’s Club engaged in numerous fundraising activities including operating both a cafeteria and a gas station in order to afford the construction. Architecturally the building, designed by local architect Thomas Jones, is a good example of the Colonial Revival style, and an example of a purpose-built clubhouse erected during a pre-Depression boom in woman's club clubhouse construction in North Carolina.
Hanbury Preservation Consulting prepared the National Register nomination for the building, now the Wayne County Museum, and it was listed in December 2022.